ANSWER: No, There is no evidence to suggest that D-mannose can irritate the bladder.
In fact, some people use D-mannose as a natural remedy for bladder irritation and urinary tract infections (UTIs).
However, it is always best to consult with a healthcare provider before using any natural remedy for a medical condition.
Everyone is different and what works for some people may not work for others. It is important to work with a healthcare provider to develop a treatment plan that is right for you.